STUDIES ON THE MODE OF ACTION OF ANALOGUES OF OROTIC ACID: 6-URACILSULFONIC ACID, 6-URACILSULFONAMIDE, AND 6-URACIL METHYL SULFONE
نویسندگان
چکیده
منابع مشابه
Biological Studies of Analogs of Orotic Acid : 6—Uracil sulfonic Acid, 6-Uracilsulfonamide, and 6-Uracil Methyl Sulfone * WILLIAM L. HOLMES AND ARNOLD D. WELCH
Investigations of the metabolism of orotic acid have shown that this compound is utilized by cer thin bacteria (@O)and by the mammal for the syn thesis of pentosenucleic acid (1, 5). Although it has not been definitely established that orotic acid (or a metabolic derivative of it) is an obligatory inter mediate in the biosynthesis of nucleic acids, there is considerable evidence in support of t...
متن کاملStudies on 6-uracil methyl sulfone. II. Anti-tumor activity.
MATERIALS AND METHODS Male and female AKR X DBA/2 mice,16-8 weeks old and weighing 18-25 gm., were used in our studies of lymphomas L12101 and L5178-Y.»Female Swiss mice of the Ha/ICR strain,' also 6-8 weeks old and weighing 20-25 gm., were used in our studies of Sarcoma 180, drug toxicity, and metabolism. Purina Laboratory Chow and drinking water were available ad libitum. Solutions of UMS' w...
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چکیده ندارد.
15 صفحه اولStudies on the mechanism of action of 6-uracil methyl sulfone in mouse Ehrlich ascites tumor cells in vitro.
Orotic acid is utilized by many mammalian and bacterial systems for the biosynthesis of the pyrimidines found in ribonucleic (UNA) and deoxyribonucleic (DNA) acids. 6-Uracil methyl sulfone (UMS) is one of several orotic acid analogs which have been synthesized and studied by Greenbaum, Hohnes, and Welch (1, 2, 15). Hohnes and Welch have shown (4) that UMS noncompetitively inhibits the growth of...
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Recent work has shown that certain growth inhibitory purine analogues undergo anabolism to ribonucleoside 5’-phosphates (1, 2). Ribonucleoside 5’-phosphate derivatives of purine analogues that effect temporary remission of some human leukemias have been synthesized (3-6), and effects of these nucleotides on enzymatic interconversions of naturally occurring purine nucleotides have been studied (...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1956
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65067-7